Grant Deadlines
OpenCooperative agreementUp to $3M per award

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services · PAR-25-446

In plain English

National Institutes of Health (Department of Health and Human Services) is accepting applications for this cooperative agreement until Aug 21, 2028 (649 days left).

Awards are up to $3,000,000 each.

Eligible applicant types include nonprofits, small businesses, for-profit companies, state governments, local governments, tribal governments & organizations, colleges & universities, school districts and public housing authorities, plus others described in the listing.

The listing says cost sharing or matching is not required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Key facts

StatusPosted: open for applications
Close dateAug 21, 2028 · 649 days left
Posted dateSep 10, 2025
Opportunity numberPAR-25-446
AgencyNational Institutes of Health (Department of Health and Human Services)
Funding instrumentCooperative agreement
CategoryEducation, Health
Opportunity categoryDiscretionary
Award ceiling (max per award)$3,000,000
Award floor (min per award)Not stated
Estimated total program fundingNot stated
Expected number of awardsNot stated
Cost sharing or matching requiredNo
Assistance listing (CFDA/ALN)93.279 – Drug Use and Addiction Research Programs
Last updated on Grants.govSep 10, 2025
Archive dateSep 26, 2028

Who can apply

Browse similar: Nonprofits · Small businesses · For-profit companies · State governments · Local governments · Tribal governments & organizations · Colleges & universities · School districts · Public housing authorities

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Native American tribal governments (federally recognized)
  • Public housing authorities / Indian housing authorities
  • Native American tribal organizations (other than federally recognized tribal governments)
  • Nonprofits with 501(c)(3) status (other than institutions of higher education)
  • Nonprofits without 501(c)(3) status (other than institutions of higher education)
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others (see the eligibility details in the listing)

Additional eligibility information (excerpt from the listing):

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Description

Excerpt from the official synopsis on Grants.gov (shortened; read the full text on the official listing):

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Read the full listing on Grants.gov → · Agency's announcement page

Before you apply: organizations applying through Grants.gov generally need an active SAM.gov registration (with a Unique Entity ID) and a Grants.gov account, and registration can take several weeks, so start early. Check the official listing for the exact requirements, deadline time and time zone. This page is a summary, not the official notice, and not legal or financial advice.

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