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BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services · RFA-DA-27-004

In plain English

National Institutes of Health (Department of Health and Human Services) is accepting applications for this grant until Nov 8, 2027 (362 days left).

The listing does not state award amounts or the number of awards.

Eligible applicant types include nonprofits, small businesses, for-profit companies, state governments, local governments, tribal governments & organizations, colleges & universities, school districts and public housing authorities, plus others described in the listing.

The listing says cost sharing or matching is not required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Key facts

StatusPosted: open for applications
Close dateNov 8, 2027 · 362 days left
Posted dateSep 16, 2025
Opportunity numberRFA-DA-27-004
AgencyNational Institutes of Health (Department of Health and Human Services)
Funding instrumentGrant
CategoryEducation, Health, Income Security and Social Services
Opportunity categoryDiscretionary
Award ceiling (max per award)Not stated
Award floor (min per award)Not stated
Estimated total program fundingNot stated
Expected number of awardsNot stated
Cost sharing or matching requiredNo
Assistance listing (CFDA/ALN)93.173 – Research Related to Deafness and Communication Disorders
93.213 – Research and Training in Complementary and Integrative Health
93.242 – Mental Health Research Grants
93.273 – Alcohol Research Programs
93.279 – Drug Use and Addiction Research Programs
93.286 – Discovery and Applied Research for Technological Innovations to Improve Human Health
93.372 – 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
93.853 – Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 – Child Health and Human Development Extramural Research
93.866 – Aging Research
93.867 – Vision Research
Last updated on Grants.govSep 16, 2025
Archive dateDec 14, 2027

Who can apply

Browse similar: Nonprofits · Small businesses · For-profit companies · State governments · Local governments · Tribal governments & organizations · Colleges & universities · School districts · Public housing authorities

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Native American tribal governments (federally recognized)
  • Public housing authorities / Indian housing authorities
  • Native American tribal organizations (other than federally recognized tribal governments)
  • Nonprofits with 501(c)(3) status (other than institutions of higher education)
  • Nonprofits without 501(c)(3) status (other than institutions of higher education)
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others (see the eligibility details in the listing)

Additional eligibility information (excerpt from the listing):

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Description

Excerpt from the official synopsis on Grants.gov (shortened; read the full text on the official listing):

The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. …

Read the full listing on Grants.gov → · Agency's announcement page

Before you apply: organizations applying through Grants.gov generally need an active SAM.gov registration (with a Unique Entity ID) and a Grants.gov account, and registration can take several weeks, so start early. Check the official listing for the exact requirements, deadline time and time zone. This page is a summary, not the official notice, and not legal or financial advice.

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