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NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services · PA-27-101

In plain English

National Institutes of Health (Department of Health and Human Services) is accepting applications for this grant until Apr 5, 2029 (876 days left).

The listing does not state award amounts or the number of awards.

Eligible applicant types include small businesses.

Cost sharing or matching is required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Key facts

StatusPosted: open for applications
Close dateApr 5, 2029 · 876 days left
Posted dateMay 28, 2026
Opportunity numberPA-27-101
AgencyNational Institutes of Health (Department of Health and Human Services)
Funding instrumentGrant
CategoryHealth
Opportunity categoryDiscretionary
Award ceiling (max per award)Not stated
Award floor (min per award)Not stated
Estimated total program fundingNot stated
Expected number of awardsNot stated
Cost sharing or matching requiredYes
Assistance listing (CFDA/ALN)93.233 – National Center on Sleep Disorders Research
93.242 – Mental Health Research Grants
93.273 – Alcohol Research Programs
93.307 – Minority Health and Health Disparities Research
93.313 – NIH Office of Research on Women's Health
93.350 – National Center for Advancing Translational Sciences
93.351 – Research Infrastructure Programs
93.393 – Cancer Cause and Prevention Research
93.394 – Cancer Detection and Diagnosis Research
93.395 – Cancer Treatment Research
93.837 – Cardiovascular Diseases Research
93.838 – Lung Diseases Research
Last updated on Grants.govJun 1, 2026
Archive dateJun 4, 2029

Who can apply

Browse similar: Small businesses

  • Small businesses

Additional eligibility information (excerpt from the listing):

Only United States small business concerns (SBCs) that have previously received an NIH SBIR or STTR Phase II award are eligible to submit applications for this opportunity. Only one NIH Phase IIB Strategic Breakthrough award is allowed per project. This NOFO supports Renewal/Resubmission "Type 2" Applications from recipients with NIH Phase II SBIR/STTR awards that are submitted within the first six due dates following the expiration of their budget period. Refer to Section III. …

Description

Excerpt from the official synopsis on Grants.gov (shortened; read the full text on the official listing):

The NIH Phase IIB Strategic Breakthrough award bridges the funding gap between the end of a Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Phase II award and commercialization. The Phase IIB Strategic Breakthrough provides previously funded NIH SBIR or STTR projects additional support for later-stage research and development (R&D).

Read the full listing on Grants.gov →

Before you apply: organizations applying through Grants.gov generally need an active SAM.gov registration (with a Unique Entity ID) and a Grants.gov account, and registration can take several weeks, so start early. Check the official listing for the exact requirements, deadline time and time zone. This page is a summary, not the official notice, and not legal or financial advice.

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