Selective Precision Targeting (SPoT)

In plain English

National Institutes of Health (Department of Health and Human Services) has announced this as a forecast: an opportunity it expects to post. It is not open for applications yet. Estimated posting date: Dec 15, 2025 (this estimate has passed and the agency has not posted it yet). Estimated application due date: Feb 17, 2026.

The agency expects to make 5 awards and estimated total program funding is $1,500,000.

Eligible applicant types include nonprofits, small businesses, for-profit companies, state governments, local governments, tribal governments & organizations, colleges & universities, school districts and public housing authorities.

The listing says cost sharing or matching is not required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Browse similar: Nonprofits · Small businesses · For-profit companies · State governments · Local governments · Tribal governments & organizations · Colleges & universities · School districts · Public housing authorities

• State governments
• County governments
• Independent school districts
• Public and state-controlled institutions of higher education
• Native American tribal governments (federally recognized)
• Public housing authorities / Indian housing authorities
• Native American tribal organizations (other than federally recognized tribal governments)
• Nonprofits with 501(c)(3) status (other than institutions of higher education)
• Private institutions of higher education
• For-profit organizations other than small businesses
• Small businesses

Excerpt from the official forecast on Grants.gov (shortened; read the full text on the official listing):

The National Center for Advancing Translational Science (NCATS) seeks to advance its mission by establishing a new initiative called Selective Precision Targeting (SPoT) to determine a mechanism for precise and on-target therapeutic drug delivery to specific hard-to-reach locations within the human body using microphysiological systems (MPS). Targeted drug-delivery systems, including engineered nanoparticles, extracellular vesicles or focused ultrasound, are methods for delivering medications to a specific area of the body (organ, tissue, or cell) to increase the concentration of the drug in that area. Hard-to-reach locations in the body include the blood–brain barrier, central nervous system, placenta, retina, or a tumor. …

Read the full forecast on Grants.gov →