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OpenGrantUp to $8M per award

BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services · RFA-NS-27-002

In plain English

National Institutes of Health (Department of Health and Human Services) is accepting applications for this grant until Jun 23, 2028 (590 days left).

Awards are up to $8,000,000 each, the agency expects to make 5 awards and estimated total program funding is $1,000,000.

Eligible applicant types include nonprofits, small businesses, for-profit companies, state governments, local governments, tribal governments & organizations, colleges & universities, school districts and public housing authorities, plus others described in the listing.

The listing says cost sharing or matching is not required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Key facts

StatusPosted: open for applications
Close dateJun 23, 2028 · 590 days left
Posted dateAug 31, 2026
Opportunity numberRFA-NS-27-002
AgencyNational Institutes of Health (Department of Health and Human Services)
Funding instrumentGrant
CategoryHealth
Opportunity categoryDiscretionary
Award ceiling (max per award)$8,000,000
Award floor (min per award)Not stated
Estimated total program funding$1,000,000
Expected number of awards5
Cost sharing or matching requiredNo
Assistance listing (CFDA/ALN)93.173 – Research Related to Deafness and Communication Disorders
93.213 – Research and Training in Complementary and Integrative Health
93.242 – Mental Health Research Grants
93.273 – Alcohol Research Programs
93.279 – Drug Use and Addiction Research Programs
93.286 – Discovery and Applied Research for Technological Innovations to Improve Human Health
93.372 – 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
93.853 – Extramural Research Programs in the Neurosciences and Neurological Disorders
93.865 – Child Health and Human Development Extramural Research
93.866 – Aging Research
93.867 – Vision Research
Last updated on Grants.govAug 31, 2026
Archive dateAug 22, 2028

Who can apply

Browse similar: Nonprofits · Small businesses · For-profit companies · State governments · Local governments · Tribal governments & organizations · Colleges & universities · School districts · Public housing authorities

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Native American tribal governments (federally recognized)
  • Public housing authorities / Indian housing authorities
  • Native American tribal organizations (other than federally recognized tribal governments)
  • Nonprofits with 501(c)(3) status (other than institutions of higher education)
  • Nonprofits without 501(c)(3) status (other than institutions of higher education)
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others (see the eligibility details in the listing)

Additional eligibility information (excerpt from the listing):

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. …

Description

Excerpt from the official synopsis on Grants.gov (shortened; read the full text on the official listing):

This Notice of Funding Opportunity (NOFO) supports transdisciplinary research teams seeking to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular building blocks give rise to central nervous system (CNS) function. Teams must integrate expertise spanning molecular and cellular through systems neuroscience, with strong collaboration between experimental and computational investigators, to bridge cells, circuits, and behavior in a unified framework that yields mechanistic insight.Applications must explicitly connect three core elements: (1) characterization of circuit components (e.g., cell types and/or connectivity); (2) measurement of dynamic circuit activity, incorporating in vivo CNS recordings at cellular and sub-second temporal resolution; and (3) analyses of a tractable behavior or functional output.To address this significant challenge …

Read the full listing on Grants.gov →

Before you apply: organizations applying through Grants.gov generally need an active SAM.gov registration (with a Unique Entity ID) and a Grants.gov account, and registration can take several weeks, so start early. Check the official listing for the exact requirements, deadline time and time zone. This page is a summary, not the official notice, and not legal or financial advice.

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