BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
National Institutes of Health · Department of Health and Human Services · RFA-NS-28-010
In plain English
National Institutes of Health (Department of Health and Human Services) is accepting applications for this cooperative agreement until Feb 8, 2029 (820 days left).
The agency expects to make 5 awards and estimated total program funding is $8,000,000.
Eligible applicant types include nonprofits, small businesses, for-profit companies, state governments, local governments, tribal governments & organizations, colleges & universities, school districts and public housing authorities, plus others described in the listing.
The listing says cost sharing or matching is not required.
Built only from the fields in the Grants.gov listing. Always confirm on the official listing.
Key facts
| Status | Posted: open for applications |
|---|---|
| Close date | Feb 8, 2029 · 820 days left |
| Posted date | Sep 30, 2026 |
| Opportunity number | RFA-NS-28-010 |
| Agency | National Institutes of Health (Department of Health and Human Services) |
| Funding instrument | Cooperative agreement |
| Category | Health |
| Opportunity category | Discretionary |
| Award ceiling (max per award) | Not stated |
| Award floor (min per award) | Not stated |
| Estimated total program funding | $8,000,000 |
| Expected number of awards | 5 |
| Cost sharing or matching required | No |
| Assistance listing (CFDA/ALN) | 93.173 – Research Related to Deafness and Communication Disorders 93.213 – Research and Training in Complementary and Integrative Health 93.242 – Mental Health Research Grants 93.273 – Alcohol Research Programs 93.279 – Drug Use and Addiction Research Programs 93.286 – Discovery and Applied Research for Technological Innovations to Improve Human Health 93.372 – 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies 93.853 – Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 – Child Health and Human Development Extramural Research 93.866 – Aging Research 93.867 – Vision Research |
| Last updated on Grants.gov | Sep 30, 2026 |
| Archive date | Apr 10, 2029 |
Who can apply
Browse similar: Nonprofits · Small businesses · For-profit companies · State governments · Local governments · Tribal governments & organizations · Colleges & universities · School districts · Public housing authorities
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Native American tribal governments (federally recognized)
- Public housing authorities / Indian housing authorities
- Native American tribal organizations (other than federally recognized tribal governments)
- Nonprofits with 501(c)(3) status (other than institutions of higher education)
- Nonprofits without 501(c)(3) status (other than institutions of higher education)
- Private institutions of higher education
- For-profit organizations other than small businesses
- Small businesses
- Others (see the eligibility details in the listing)
Additional eligibility information (excerpt from the listing):
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. …
Description
Excerpt from the official synopsis on Grants.gov (shortened; read the full text on the official listing):
This funding opportunity supports transformative, mechanistic research aimed at understanding how the human brain functions. Applications should seek to reveal how the dynamic activity of individual neurons and ensembles of neurons within spatially organized brain networks gives rise to internal experiences, such as sensations, perceptions, emotions, thoughts, and memories, as well as to observable motor and social behaviors. To achieve fundamental mechanistic insights into human brain function, proposed studies are expected to leverage opportunities made possible by invasive surgical procedures in humans, such as intracranial recording or stimulation. These investigations may be enhanced by incorporating complementary experimental models or systems that provide access to knowledge, techniques, or resources not otherwise available in human neuroscience research. …
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