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Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services · PAR-27-039

In plain English

National Institutes of Health (Department of Health and Human Services) has announced this as a forecast: an opportunity it expects to post. It is not open for applications yet. Estimated posting date: Nov 5, 2026 (this estimate has passed and the agency has not posted it yet). Estimated application due date: Jan 5, 2027.

The listing does not state award amounts or the number of awards.

Eligible applicant types include small businesses.

The listing says cost sharing or matching is not required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Key facts

StatusForecasted: not open yet
Estimated posting dateNov 5, 2026 (estimate has passed)
Estimated application due dateJan 5, 2027
Estimated award dateJun 1, 2027
Estimated project startJul 1, 2027
Fiscal year2027
Forecast postedMay 27, 2026
Opportunity numberPAR-27-039
AgencyNational Institutes of Health (Department of Health and Human Services)
Funding instrumentGrant
CategoryHealth
Opportunity categoryDiscretionary
Award ceiling (max per award)Not stated
Award floor (min per award)Not stated
Estimated total program fundingNot stated
Expected number of awardsNot stated
Cost sharing or matching requiredNo
Assistance listing (CFDA/ALN)93.113 – Environmental Health
93.121 – Oral Diseases and Disorders Research
93.143 – NIEHS Superfund Hazardous Substances_Basic Research and Education
93.172 – Human Genome Research
93.173 – Research Related to Deafness and Communication Disorders
93.213 – Research and Training in Complementary and Integrative Health
93.233 – National Center on Sleep Disorders Research
93.273 – Alcohol Research Programs
93.279 – Drug Use and Addiction Research Programs
93.350 – National Center for Advancing Translational Sciences
93.361 – Nursing Research
93.837 – Cardiovascular Diseases Research
Last updated on Grants.govMay 27, 2026

Who can apply

Browse similar: Small businesses

  • Small businesses

Additional eligibility information (excerpt from the listing):

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

Description

Excerpt from the official forecast on Grants.gov (shortened; read the full text on the official listing):

The National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC), including the participating Institutes, Centers and Offices, intend to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I, and Fast-Track (NIH only) grant applications for the Small Business Transition Grant. Through this NOFO, NIH and CDC will support early-career scientists as they transition into entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI. Applications are not being solicited at this time. …

Read the full forecast on Grants.gov →

Before you apply: organizations applying through Grants.gov generally need an active SAM.gov registration (with a Unique Entity ID) and a Grants.gov account, and registration can take several weeks, so start early. Check the official listing for the exact requirements, deadline time and time zone. This page is a summary, not the official notice, and not legal or financial advice.

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