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BRAIN Initiative: Development and Validation of Novel Tools and New Approaches for Neuroscience Research

National Institutes of Health · Department of Health and Human Services · RFA-MH-28-110

In plain English

National Institutes of Health (Department of Health and Human Services) has announced this as a forecast: an opportunity it expects to post. It is not open for applications yet. Estimated posting date: Feb 10, 2027. Estimated application due date: Jun 10, 2027.

The agency expects to make 10 awards and estimated total program funding is $12,000,000.

Eligible applicant types include nonprofits, small businesses, for-profit companies, state governments, local governments, tribal governments & organizations, colleges & universities, school districts and public housing authorities, plus others described in the listing.

The listing says cost sharing or matching is not required.

Built only from the fields in the Grants.gov listing. Always confirm on the official listing.

Key facts

StatusForecasted: not open yet
Estimated posting dateFeb 10, 2027
Estimated application due dateJun 10, 2027
Estimated award dateApr 1, 2028
Estimated project startApr 1, 2028
Fiscal year2028
Forecast postedJun 24, 2026
Opportunity numberRFA-MH-28-110
AgencyNational Institutes of Health (Department of Health and Human Services)
Funding instrumentGrant
CategoryHealth
Opportunity categoryDiscretionary
Award ceiling (max per award)Not stated
Award floor (min per award)Not stated
Estimated total program funding$12,000,000
Expected number of awards10
Cost sharing or matching requiredNo
Assistance listing (CFDA/ALN)93.242 – Mental Health Research Grants
Last updated on Grants.govJun 25, 2026

Who can apply

Browse similar: Nonprofits · Small businesses · For-profit companies · State governments · Local governments · Tribal governments & organizations · Colleges & universities · School districts · Public housing authorities

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public and state-controlled institutions of higher education
  • Native American tribal governments (federally recognized)
  • Public housing authorities / Indian housing authorities
  • Native American tribal organizations (other than federally recognized tribal governments)
  • Nonprofits with 501(c)(3) status (other than institutions of higher education)
  • Nonprofits without 501(c)(3) status (other than institutions of higher education)
  • Private institutions of higher education
  • For-profit organizations other than small businesses
  • Small businesses
  • Others (see the eligibility details in the listing)

Additional eligibility information (excerpt from the listing):

Other Eligible ApplicantsEligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Description

Excerpt from the official forecast on Grants.gov (shortened; read the full text on the official listing):

The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for research to develop novel tools and approaches that enable the interrogation of cell-specific and circuit-specific processes in the central nervous system. This NOFO consolidates three current BRAIN Initiative tool development programs. Projects that focus on developing a broad range of new research tools to delineate anatomical and functional connections between cells and circuits, and to expand our knowledge of brain architecture and function are encouraged, such as projects that: • Develop novel tools to characterize/define cell-types, circuits, and cellular components in the nervous system with greater selectivity and sensitivity, including: • new genetic or non-genetic technologies/approaches (for delivering …

Read the full forecast on Grants.gov →

Before you apply: organizations applying through Grants.gov generally need an active SAM.gov registration (with a Unique Entity ID) and a Grants.gov account, and registration can take several weeks, so start early. Check the official listing for the exact requirements, deadline time and time zone. This page is a summary, not the official notice, and not legal or financial advice.

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